Highly sensitive C-reactive protein (hsCRP) is made by the liver in response to infection, tissue injury or inflammation. Even low values, previously regarded as normal, have been shown to be a risk factor for atherosclerosis (fatty deposits lining the walls of blood vessels). Results of this test can help predict your risk of developing atherosclerotic heart disease. Buildup of these fatty deposits can cause chest pain, called angina, and eventually lead to a heart attack. Your risk increases with increasing levels of CRP.